Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis

Recruiting now · Not applicable

Conditions studied: Periodontal Diseases, Periodontitis

In brief

Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consumption of nitrates from vegetables can modify the oral microbiota by increasing species with nitrate-reducing capacity, which are also bacteria that are associated with oral health.

Key facts

Study ID

NCT05232331

Run by

University of Guadalajara

People needed

60

Starts

2021-06-23

Expected to finish

2025-12-31

Last updated by the study team

2024-08-16

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and/or women from 30 to 65 years old
• Voluntary participation and signing the written informed consent
• Not receiving nutritional treatment at the time of uptake
• Availability to attend all scheduled visits
• Have an indication to receive nonsurgical periodontal treatment (NSPT)
• Interdental clinical insertion loss ≥3mm and ≥5mm in the buccal or oral area of two or more non-adjacent teeth
• Detectable depths ≥ 5mm in two or more teeth
• Radiographic evidence of periodontal bone loss

You may not qualify if…

• Trauma-Induced Gingival Recessions
• Cervical caries
• History of bleeding diathesis
• Pregnant or nursing women
• BMI <18.5 kg / m2
• History of any of the following self-reported diseases: type 2 diabetes mellitus, high blood pressure, kidney or liver disease, inflammatory bowel diseases, autoimmune diseases and/ or use of medications to control these diseases.
• Having or presenting a high risk of infection by tuberculosis, hepatitis B or Human Immunodeficiency Virus (HIV)
• Use of antibiotics (including antibiotic oral rinse) 6 months prior to or during the study
• Having received specialized periodontal treatment in the previous 6 months.
• Smoking habit
• Require an interpreter or not understand Spanish to attend or provide written material.

Where it is running

• Integral Dental Clinics CUCS UDG — Guadalajara, Jalisco, Mexico (enrolling)

Full record on ClinicalTrials.gov

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