Stress Phenotypes and Preterm Birth
Recruiting now · Not applicable
Conditions studied: Preterm Birth, Inflammation, Stress, Mental Health Issue
In brief
Pregnancy ends in preterm birth (PTB) for approximately 1 in 10 women, though more often for Non-Hispanic Black women, 14.12% PTB rate, compared to 9.09% for Non-Hispanic White women. Psychosocial stress and childhood trauma each are associated with risk for PTB and PTB has an intergenerational impact: mothers born preterm are more likely to give birth preterm, especially amongst Black women. In this project, we will study mitochondria, which contain their own genome, the mitochondria DNA, and are inherited from the mother, as they represent a potential intersection point between psychosocial experiences and their biological embedding in underlying disease outcomes such as PTB
Key facts
- Study ID
- NCT05229666
- Run by
- Columbia University
- People needed
- 200
- Starts
- 2021-12-09
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Pregnant women 18 years of age or older (based on self-report)
- Not currently smoking, drinking alcohol, or taking drugs (based on self-report)
- Planning to deliver at CUIMC/NYP (based on self-report)
- In the first or second trimester of pregnancy (prior to 28 weeks gestation) (based on self-report of estimated date of delivery)
You may not qualify if…
- Multi-fetal pregnancy (based on self-report)
- Taking medications regularly that affect the cardiovascular and inflammatory systems, including NSAIDS and other anti-inflammatories, α blockers, β blockers, corticosteroids, chronic-use asthma medications (e.g. beta2- adrenoceptor agonists) (based on self-report)
- This does NOT include baby aspirin or low-dose aspirin, as baby aspirin / low-dose aspirin is not normally considered to be an NSAID.
- Inflammatory conditions including rheumatoid arthritis, lupus, and multiple sclerosis (based on self-report)
Where it is running
- Columbia University Irving Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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