Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)

Recruiting now · Not applicable

Conditions studied: Mechanical Ventilation Complication, Pulmonary Edema

In brief

The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.

Key facts

Study ID

NCT05226247

Run by

Centre Hospitalier Universitaire de Nice

People needed

250

Starts

2022-08-08

Expected to finish

2026-09-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Invasive mechanical ventilation for more than 48 hours
• Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:
• SpO2> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O
• Cough effectiveness on tracheal aspirations
• Lack of hemodynamic instability and of disorders of consciousness
• Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:
• Obesity, defined by a body mass index> 30 kg/m²
• Chronic obstructive pulmonary disease
• Chronic heart disease

You may not qualify if…

• Age <18 years and pregnant women
• Patients with a decision of not to resuscitate
• Poor echogenicity
• Severe mitral valve disease (leakage and/or stenosis, bioprosthesis)
• Patients with pacemaker
• Tracheostomy
• Chronic neuromuscular or neurodegenerative diseases

Where it is running

• CHU de Dijon — Dijon, France (enrolling)
• CHU de NICE — Nice, France (enrolling)
• Hôpital Cochin — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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