Platelet Rich Plasma for Uterine Scar

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Cesarean Section Complications, Uterine Bleeding, Pelvic Pain, Menstrual Irregularity

In brief

When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.

Key facts

Study ID

NCT05224726

Run by

The University of Texas Health Science Center, Houston

People needed

40

Starts

2025-07-19

Expected to finish

2028-07-01

Last updated by the study team

2025-08-26

Who can join

Age: 18 and older, up to 52. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women undergoing elective cesarean delivery
• Term pregnancy (≥37 weeks of gestation)

You may not qualify if…

• Thrombocytopenia (CBC Platelet count <70,000)
• Connective tissue disease
• Uterine scars other than cesarean (s/p myomectomy, s/p cornual resection)
• Malformed uterus (unicornuate, bicornuate, didelphic)

Where it is running

• Sheba Medical Center — Ramat Gan, Center, Israel (enrolling)

Full record on ClinicalTrials.gov

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