Interpretation Bias as a Mechanism of Treatment Response in OCD
Recruiting now · Not applicable
Conditions studied: Obsessive-Compulsive Disorder
In brief
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I. Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.
Key facts
- Study ID
- NCT05224414
- Run by
- Mclean Hospital
- People needed
- 106
- Starts
- 2022-03-30
- Expected to finish
- 2026-08-31
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1) OCD Institute patients
- 2) adults (> 18 years old)
- 3) able to complete a computer task for 20 minutes
- 4) consent to main OCD Institute study protocol
- 5) primary diagnosis of OCD (as measured by a score of >16 on the Y-BOCS and a clinical diagnosis of OCD by their treatment team
- 6) score of >131 on the Obsessive Beliefs Questionnaire-44 at admission [which is 1 SD above the mean score of the non-clinical sample reported in the original validation paper by the Obsessive Compulsive Cognitions Working Group (2005)]
You may not qualify if…
- 1) Currently experiencing acute symptoms of psychosis
- 2) Psychotic disorder diagnosis
Where it is running
- McLean Hospital — Belmont, Massachusetts, United States (enrolling)
Full record on ClinicalTrials.gov
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