Avalanche Phenomenon During Airways Opening in Acute Respiratory Distress Syndrome
Recruiting now
Conditions studied: Acute Respiratory Distress Syndrome
In brief
Acute respiratory distress syndrome accounts for 23% of mechanically ventilated patients and is associated with high mortality rate. Although life-saving, mechanical ventilation may worsen lung injury through two main mechanisms: lung overdistension and atelectrauma. Indeed, the cyclic opening and closure of airways during tidal ventilation may cause lung and bronchial injuries as suggested by animal models and autopsy findings. Complete airways closure has recently been described in 40% of patients with acute respiratory distress syndrome, and setting positive end-expiratory pressure above the airway opening pressure may limit atelectrauma. However, animal and mathematical models suggest that above the airway opening pressure, more distal airways open unevenly according to their own opening pressure, resulting in an "avalanche"-like phenomenon during lung inflation. This phenomenon has never been described in humans. A better understanding of the opening of airways in acute respiratory distress syndrome may help to limit ventilation-induced lung injury and to improve outcomes.
Key facts
- Study ID
- NCT05224323
- Run by
- Poitiers University Hospital
- People needed
- 50
- Starts
- 2022-03-01
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2025-12-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18
- Moderate-to-severe acute respiratory distress syndrome within the first 72 hours after meeting the Berlin definition criteria:
- Within 1 week of a known clinical insult or new or worsening respiratory symptoms;
- Bilateral opacities (not fully explained by effusions, lobar/lung collapse, or nodules);
- Respiratory failure not fully explained by cardiac failure or fluid overload;
- PaO2/FiO2 ≤ 200 mmHg with positive end-expiratory pressure ≥ 5 cmH2O.
- Absence of spontaneous breathing efforts
- Consent to participate to the study from the patient and/or its surrogate
You may not qualify if…
- Pneumothorax
- Broncho-pleural fistula
- Tracheostomy
- Hemodynamic instability
- Severe hypoxemia
- Suspected of proven intracranial hypertension
- Chronic obstructive lung disease
- Pacemaker or defibrillator
- Decision to withhold of withdraw life-sustaining measures
- Under protection
Where it is running
- CHU Poitiers — Poitiers, France (enrolling)
Full record on ClinicalTrials.gov
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