Safety and Pharmacokinetics Study of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in R-R DLBCL Patients
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Diffuse Large B Cell Lymphoma
In brief
This is an open-label, multicentre study too Evaluate the Safety and Pharmacokinetics of a Modified Tafasitamab IV Dosing Regimen Combined with Lenalidomide (LEN) in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL) who have had at least one, but no more than three prior systemic regimens and who are not eligible for high dose chemotherapy (HDC) with autologous stem-cell transplantation (ASCT) at the time of study entry.
Key facts
- Study ID
- NCT05222555
- Run by
- Incyte Corporation
- People needed
- 53
- Starts
- 2022-07-19
- Expected to finish
- 2027-11-30
- Last updated by the study team
- 2026-01-16
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Texas Oncology-Baylor Charles A. Sammons Cancer Center - USOR — Dallas, Texas, United States
- Vista Oncology — Olympia, Washington, United States
- UK St. Pölten — Sankt Pölten, Lower Austria, Austria
- Klinikum Wels Grieskirchen — Wels, Upper Austria, Austria
- Universitatsklinikum Salzburg — Salzburg, Austria
- Fakultni nemocnice Brno — Brno, Czechia
- Fakultni nemocnice Ostrava — Ostrava, Czechia
- Fakultni nemocnice Kralovske Vinohrady — Prague, Czechia
- Vseobecna Fakultni Nemocnice V Praze — Prague, Czechia
- Fakultni nemocnice v Motole — Prague, Czechia
- Centre Hospitalier Universitaire Grenoble Alpes - Hopital Albert Michallon — Grenoble, Isère, France
- CHU Nantes — Nantes, Loire-Atlantique, France
- Centre Hospitalier Le Mans — Le Mans, Sarthe, France
- CHU de Poitiers — Poitiers, Vienne, France
- Soroka University Medical Centre — Beersheba, Southern District, Israel
- Shamir Medical Center Assaf Harofeh — Be’er Ya‘aqov, Israel
- Lady Davis Carmel Medical Center — Haifa, Israel
- Hadassah Medical Center - Hadassah Ein Kerem — Jerusalem, Israel
- ZIV Medical Center — Safed, Israel
- Ospedale Santa Maria Delle Croci — Ravenna, Emilia-Romagna, Italy
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico — Milan, Lombardy, Italy
- ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda — Milan, Lombardy, Italy
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Lombardy, Italy
- ASST di Monza - Azienda Ospedaliera San Gerardo — Monza, Monza E Brianza, Italy
- Morristown Memorial Hospital — Morristown, New Jersey, United States
Full record on ClinicalTrials.gov
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