Cryoablation as a Minimally Invasive Alternative to Surgery for Managing Ductal Carcinoma In Situ

Recruiting now · Not applicable

Conditions studied: Ductal Carcinoma in Situ

In brief

Cryoablation or tumor freezing is a percutaneous, office-based procedure that is emerging as a minimally invasive, cost-effective alternative to surgery that is currently being evaluated in clinical trials for the management of for early-stage invasive breast cancer. The investigator will also evaluate the potential of cryoablation as a minimally invasive alternative to surgery for small areas of DCIS by examining its ability to achieve complete ablation of DCIS within the targeted cryoablation zone of necrosis.

Key facts

Study ID

NCT05218044

Run by

Glendale Adventist Medical Center d/b/a Adventist Health Glendale

People needed

30

Starts

2021-11-01

Expected to finish

2026-11-01

Last updated by the study team

2023-03-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• DCIS spanning 2 cm or less based on its radiographic appearance by mammography and/or breast contrast-enhanced MRI
• Diagnosis of DCIS by minimally invasive needle biopsy
• No prior history of DCIS or invasive breast cancer in the same breast
• No history of surgical biopsy and/or lumpectomy for diagnosis/treatment in the same breast
• Adequate breast volume and skin clearance to permit cryoablation as assessed by Dr. Holmes. This excludes male and females with breasts too small to allow safe cryoablation
• Non-pregnant, non-lactating, and no history of pregnancy within the preceding 6 months
• No history of breast radiation in the same breast

Where it is running

• Office of Dennis R. Holmes, M.D., F.A.C.S. — Glendale, California, United States (enrolling)

Full record on ClinicalTrials.gov

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