Effects of Daily Supplementation of 5-HTP on Body Composition

Completed · Not applicable · Has a placebo group

Conditions studied: Body Composition

In brief

The purpose of this investigation was to compare supplementation with 5-HTP to placebo on indices of body composition. A randomized trial compared a sample of 48 resistance-trained individuals taking either 100 mg of 5-hydroxytryptophan supplementation or a placebo. The investigators tested anthropometric measurements using a multi-frequency bioelectrical impedance device (InBody® 270). The primary outcome (i.e., changes in anthropometric measurements) was assessed at the first visit (pre-test-) and post-test (8 weeks). Secondary outcomes include resting heart rate, blood pressure, and dietary intake.

Key facts

Study ID

NCT05216406

Run by

Nova Southeastern University

People needed

65

Starts

2021-01-01

Expected to finish

2021-05-15

Last updated by the study team

2025-02-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy or free of disease
• Minimum of 1 year of regular physical activity. Regular physical activity is defined by a minimum of 150 minutes of aerobic activity or performing muscle-strengthening exercises at least 2 days a week.

You may not qualify if…

• Physically inactive
• Regularly used sleep aids of any kind
• Currently taking selective serotonin reuptake inhibitors (SSRIs) and/or 5-HTP containing supplements.

Where it is running

• IHP — Boca Raton, Florida, United States

Full record on ClinicalTrials.gov

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