Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

Running, not enrolling · Phase 1

Conditions studied: Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer, Cervical Cancer, Endocervical Cancer, Squamous Cell Carcinoma of Head and Neck, Bladder Urothelial Cancer, Colorectal Carcinoma, Esophageal Cancer, Ovarian Cancer, Renal Cell Carcinoma, Prostate Cancer, Melanoma, Mesothelioma, Cholangiocarcinoma

In brief

Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

Key facts

Study ID

NCT05215574

Run by

NGM Biopharmaceuticals, Inc

People needed

130

Starts

2022-03-31

Expected to finish

2026-03-01

Last updated by the study team

2024-10-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically or cytologically documented locally advanced or metastatic solid tumor malignancy.
• Adequate bone marrow, kidney and liver function
• Performance status of 0 or 1.
• Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade 1 except for AEs not constituting a safety risk by Investigator judgement.

You may not qualify if…

• Prior treatment targeting ILT3.
• Prior treatment targeting LAIR1.

Where it is running

• NGM Clinical Study Site — Gilbert, Arizona, United States
• NGM Clinical Study Site — Los Angeles, California, United States
• NGM Clinical Study Site — Sarasota, Florida, United States
• NGM Clinical Study Site — Tampa, Florida, United States
• NGM Clinical Study Site — Grand Rapids, Michigan, United States
• NGM Clinical Study Site — New York, New York, United States
• NGM Clinical Study Site — Oklahoma City, Oklahoma, United States
• NGM Clinical Study Site — Austin, Texas, United States
• NGM Clinical Study Site — Houston, Texas, United States

Full record on ClinicalTrials.gov

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