Cortical Contributions to FFR: Post-Op Outcomes

Enrolling by invitation · Not applicable

Conditions studied: Language

In brief

The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, but recent consensus in the literature supports the notion that it is an integrated response between subcortical and cortical neural populations. The proposed study aims to deconstruct the role of the cortex in generating and modulating the FFR. The research team will build a novel computational model of FFR mechanisms and use EEG recordings from participants who have undergone resection of lesions in Heschl's gyrus to validate model predictions.

Key facts

Study ID

NCT05214092

Run by

University of Pittsburgh

People needed

10

Starts

2023-02-14

Expected to finish

2030-01-01

Last updated by the study team

2026-01-15

Who can join

Age: 13 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals 13-25 years old
• Undergoing medically necessary surgical resection of Heschl's gyrus lesion
• Monolingual English speakers
• Receptive and expressive language within normal limits
• Normal or corrected-to-normal visual acuity
• Normal hearing acuity in each ear (as determined during an audiometric assessment)
• Nonverbal IQ within normal limits
• No history of autism spectrum disorder or attention-deficit hyperactivity disorder

You may not qualify if…

• Significant medical or neuropsychological impairment that would result in the patient being unable to participate in study activities
• History of autism or ADHD

Where it is running

• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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