To Assess Efficacy and Safety of Oral Reparixin in Patients With Fatigue and Locally Advanced / Metastatic Breast Cancer

Withdrawn before enrolling · Phase 2 · Has a placebo group

Conditions studied: Fatigue, Locally Advanced or Metastatic Breast Cancer

In brief

Primary objective: • To assess the efficacy of reparixin compared to placebo in limiting CRF in adult patients with locally advanced or metastatic breast cancer undergoing single-agent taxane chemotherapy, using FACITFatigue scale. The secondary objectives are: * To evaluate change in Quality of Life in the two treatment arms * To assess the percentage of patients treated with reparixin compared to placebo delaying and discontinuing chemotherapy * To assess Patient Global Impression of Severity (PGI-S) score and Patient Global Impression of Change (PGI-C) score associated with reparixin compared to placebo * To assess the effect of reparixin compared to placebo on ECOG PS * To assess the effects of reparixin vs placebo on Objective Response Rate (ORR), Progression Free Survival (PFS), Overall Survival (OS) The safety objective is: • To assess the safety and tolerability of reparixin in adult patients undergoing taxane-containing chemotherapy. The pharmacokinetic (PK) objective is: • To define the PK profile of orally administered reparixin, its metabolites (DF2243Y, DF2188Y, ibuprofen) and concomitant antineoplastic agents (paclitaxel, or nab-paclitaxel or docetaxel) in adult patients with locally advanced or metastatic breast cancer.

Key facts

Study ID

NCT05212701

Run by

Dompé Farmaceutici S.p.A

People needed

0

Starts

2022-04-19

Expected to finish

2024-07-01

Last updated by the study team

2024-04-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Provide written informed consent before the initiation of any study-specific procedures
• 2. Male or female ≥18 years of age
• 3. Pathologically documented locally advanced (not amenable to surgical resection) or metastatic HER2-negative breast cancer
• 4. Candidate to receive cycle 1 of treatment with single-agent taxane-based chemotherapy (paclitaxel, nab-paclitaxel, docetaxel)
• 5. CRF score from 1 to 6 on a numeric rating scale (NRS) from 0 to 10, where 0 = no fatigue, 10 = worst possible fatigue, during the previous 24 hours and lasting for a minimum of 4 days
• 6. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0-2
• 7. Life expectancy of at least 6 months as estimated by the investigator
• 8. Able to swallow and retain oral medication (intact tablet)
• 9. Adequate organ function (defined by the following parameters):
• Serum creatinine < 140 μmol/L (< 1.6 mg/dL) or creatinine clearance > 60 mL/min
• Serum hemoglobin ≥ 11 g/dL; absolute neutrophil count ≥ 1.5 x 109/L; platelets ≥ 100 x 109/L.
• Serum bilirubin ≤ upper limit of normal (ULN), except patients with Gilbert's syndrome.
• Serum Alanine aminotransferase (ALT), aspartate transaminase (AST) ≤ 1.5 x ULN
• Alkaline phosphatase ≤ 2.5 x ULN
• prothrombin time (PT) or activated partial thromboplastin time (aPTT, PTT) ≤ULN
• 10. No known hepatitis B virus (not due to immunization), hepatitis C virus, human immunodeficiency virus-I and -II positive status
• 11. If a female of childbearing potential, have a negative serum β-human chorionic gonadotropin (β-hCG) serum pregnancy test and use a highly effective method to avoid pregnancy for the duration of the trial and for at least 6 months after completion of docetaxel, paclitaxel or nab-paclitaxel therapy. Males of reproductive potential should use effective contraception during treatment and for 6 months after the last dose of docetaxel, paclitaxel or nab-paclitaxel

You may not qualify if…

• 1. More than 1 prior systemic chemotherapy for advanced disease. Patients may have received hormone therapy and biological therapy (e.g. CDK4/6 inhibitors), either alone or in combination
• 2. Malabsorption syndrome or disease significantly affecting gastrointestinal function including but not limited to gastrectomy or gastric outlet obstruction
• 3. History or evidence of neurological or psychiatric disorder or any other concurrent medical condition or disease that, in the opinion of the investigator or Medical Monitor may influence understanding of study and informed consent procedures, would pose a risk to subject safety or would interfere with the study evaluation, procedures or completion
• 4. Positive severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) antigenic test performed through nasal swab
• 5. Treatment with any investigational agent within at least 28 days or 5 half-lives (whatever is shorter) prior to Visit 1, recovered from previous treatment toxicity to Grade1 or better
• 6. Brain metastases that are untreated or symptomatic, or require any radiation, surgery, or continued steroid therapy to control symptoms from brain metastases
• 7. Treatment with oral morphine greater than 60 mg a day or equivalent
• 8. Other causes of fatigue, including, but not restricted to:
• untreated hypothyroidism
• pituitary disorder
• insomnia
• alcohol abuse
• uncontrolled pain as defined by pain intensity greater than 3 on a NRS (0-10)
• chronic >G2 anemia
• uncontrolled cardiac disease or cardiovascular disorders
• acute infections
• major depressive disorder
• uncontrolled neurological disorders
• 9. Concomitant use of other medications/dietary supplements for fatigue
• 10. Concomitant use of cannabidiol (CBD) or Tetrahydrocannabinol (THC).
• 11. Any other invasive malignancy from which the patient has been disease-free for less than 5 years with the exception of curatively treated basal or squamous cell skin cancer
• 12. Patients who are committed to an institution by virtue of an order issued either by the judicial or the administrative authorities
• 13. Patients who are employees of the sponsor or investigator or otherwise dependent on them
• 14. History of:
• intolerance or hypersensitivity to paclitaxel, nab-paclitaxel, docetaxel or any other concomitant drug used in the study

Where it is running

• Waverly Hematology — Cary, North Carolina, United States
• Tennessee Oncology, PLLC — Nashville, Tennessee, United States
• Kliniken Essen-Mitte, Klinik für Senologie/ Interdisziplinäres Brustzentrum — Essen, Germany
• Praxis für Interdisziplinäre Onkologie & Hämatologie — Freiburg im Breisgau, Germany
• Mammazentrum Hamburg am Krankenhaus Jerusalem — Hamburg, Germany
• Klinikum Ernst von Bergmann, Frauenklinik — Potsdam, Germany
• IRCCS Oncologico Istituto Tumori Giovanni Paolo II — Bari, Italy
• Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi — Bologna, Italy
• ASST-Spedali Civili di Brescia — Brescia, Italy
• E.O. Ospedali Galliera — Genova, Italy
• Istituto Scientifico Romagnolo per lo Studio e La Cura dei Tumori SRL IRCCS — Meldola (FC), Italy
• IRCCS - Istituto Europeo di Oncologia — Milan, Italy
• Azienda Ospedaliera di Perugia, Ospedale Santa Maria della Misericordia — Perugia, Italy
• Azienda Ospedaliera Universitaria Pisana — Pisa, Italy
• "Azienda Unità Sanitaria Locale della Romagna Ospedale Infermi di Rimini" — Rimini, Italy
• Istituti Fisioterapici Ospitalieri- IFO - Istituto Regina Elena — Roma, Italy
• Fondazione Policlinico Universitario A. Gemelli, IRCCS — Roma, Italy
• "Azienda Ospedaliero Universitaria Sant'Andrea " — Roma, Italy
• Ospedale Giuseppe Mazzini di Teramo — Teramo, Italy
• A.O. "Pia Fondazione Cardinale Panico" — Tricase, Italy

Full record on ClinicalTrials.gov

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