Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
Recruiting now
Conditions studied: Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
In brief
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time. Through measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD. Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex. Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).
Key facts
- Study ID
- NCT05211661
- Run by
- RWTH Aachen University
- People needed
- 15
- Starts
- 2022-10-10
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-02-09
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.
- Expected duration of invasive mechanical ventilation of at least 5 days.
You may not qualify if…
- Body-mass-index (BMI) >40
- Expected absence of active participation of the patient in study-related measurements after extubation
- Alcohol or drug abuse
- Non MRI compatible implant in the body
- Slipped disc
- Epilepsy
- Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.
Where it is running
- RWTH Aachen University — Aachen, Germany (enrolling)
Full record on ClinicalTrials.gov
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