Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD

Enrolling by invitation · Phase 2

Conditions studied: Neovascular Age-Related Macular Degeneration (nAMD)

In brief

This is a prospective study designed to evaluate the long-term safety and efficacy of ABBV-RGX-314. Eligible participants are those who were previously enrolled in a clinical study of nAMD in which they received suprachoroidal space (SCS) administration of ABBV-RGX-314. Enrollment of each participant in the current study should occur after the participant has completed either the end of study or early discontinuation visit in the previous (parent) clinical study. Participants will be followed for up to 5 years after ABBV-RGX-314 administration (inclusive of the parent study). As such, the total study duration for each participant may vary depending on when they enroll in the current study following ABBV-RGX-314 administration in the parent study.

Key facts

Study ID

NCT05210803

Run by

AbbVie

People needed

116

Starts

2021-12-20

Expected to finish

2031-07-01

Last updated by the study team

2026-08-05

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must provide written, signed informed consent for this study.
• Must have been enrolled in a previous clinical study of ABBV-RGX-314 in the treatment of nAMD and must have received an SCS injection of ABBV-RGX-314 in that study.
• Must be willing and able to comply with all study procedures.

You may not qualify if…

• None

Where it is running

• Retinal Research Institute, LLC — Phoenix, Arizona, United States
• California Retina Consultants — Bakersfield, California, United States
• Retina-Vitreous Associates Medical Group — Beverly Hills, California, United States
• Northern California Retina Vitreous Associates Medical Group Inc — Mountain View, California, United States
• Retina Consultants San Diego — Poway, California, United States
• California Retina Consultants — Santa Barbara, California, United States
• Southeast Retina Center PC — Augusta, Georgia, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Ophthalmic Consultants of Boston — Boston, Massachusetts, United States
• Vitreoretinal Surgery PLLC — Edina, Minnesota, United States
• Sierra eye Associates — Reno, Nevada, United States
• Vision Research Center Eye Associates of New Mexico — Albuquerque, New Mexico, United States
• Retinovitreous Associates, LTD — Philadelphia, Pennsylvania, United States
• Charles Retina Institute, P.C — Germantown, Tennessee, United States
• Tennessee Retina, PC — Nashville, Tennessee, United States
• Retina Consultants of Texas — The Woodlands, Texas, United States

Full record on ClinicalTrials.gov

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