Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect

Recruiting now · Not applicable

Conditions studied: Cesarean Section; Dehiscence

In brief

GnRH-a will be used to postpone period after vaginal repair for Cesarean Section Scar Defect（CSD） patients with adenomyosis which will be compared with CSD patients with adenomyosis who receive transvaginal surgery without GnRH-a, whether delayed period improving the CSD prognosis will be assessed.

Key facts

Study ID

NCT05206682

Run by

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

People needed

94

Starts

2023-05-01

Expected to finish

2027-12-30

Last updated by the study team

2026-04-24

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Clearly diagnosed with CSD complicated with adenomyosis
• Experiencing clinical features of abnormal uterine bleeding, prolonged menstrual flow (the duration of menstruation is more than 10 days).
• The thickness of the remaining muscular layer of CSD was less than 3 mm.
• Normal range of blood sugar and insulin
• No serious medical problems (important viscera function in the normal range).
• uterine fibroids no more than 5cm
• Sign the informed consent.

You may not qualify if…

• Indefinite diagnosis.
• Malignant tumors.
• With severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs).
• Pregnant.
• Mental diseases.
• Allergy to the any ingredients of Leuprorelin
• Unwilling to comply with the research plan.

Where it is running

• Shanghai Jiaotong University xinhua hospital — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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