Histamine as a Molecular Transducer of Adaptation to Exercise

Running, not enrolling · Early Phase 1 · Has a placebo group

Conditions studied: Postexercise Hypotension

In brief

This study is investigating the role of histamine in generating adaptation to exercise

Key facts

Study ID

NCT05206227

Run by

University of Oregon

People needed

80

Starts

2021-07-28

Expected to finish

2027-03-31

Last updated by the study team

2026-01-23

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 -40

You may not qualify if…

• Systolic ≥ 120
• Diastolic ≥ 80
• Body mass index (BMI) ˃ 28 kg/m2
• Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma
• Smoking or nicotine use
• Ongoing medical therapy (other than birth control)
• Ongoing use of over-the-counter or prescription antihistamines
• Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex
• Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months
• Mobility restrictions that interfere with physical activity
• High physical activity based on International Physical Activity Questionaire (IPAQ1)
• Non-English speaking

Where it is running

• University of Oregon — Eugene, Oregon, United States

Full record on ClinicalTrials.gov

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