Longitudinal Observational Biomarker Study

Completed

Conditions studied: Depression, Dementia, Mild Cognitive Impairment

In brief

The purpose of this study is to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.

Key facts

Study ID

NCT05204940

Run by

Centre for Addiction and Mental Health

People needed

506

Starts

2017-09-27

Expected to finish

2024-07-31

Last updated by the study team

2024-11-25

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women aged 60 and older
• Current Major Depressive Disorder (MDD)
• Failure to respond adequately to two or more antidepressant treatment trials of recommended dose and length
• Patient Health Questionnaire-9 (PHQ-9) score of 10 or higher

You may not qualify if…

• Dementia
• Lifetime diagnosis of bipolar I or II disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, or current psychotic symptoms.
• High risk for suicide and unable to be managed safely in the clinical trial
• Non-correctable, clinically significant sensory impairment interfering with participation
• Unstable medical illness, including delirium, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management.
• Moderate to severe substance or alcohol use disorder
• Seizure disorder.
• Parkinson's Disease
• Individuals with any contraindications to MRI

Where it is running

• UCLA Late-Life Mood, Stress, and Wellness Research Program — Los Angeles, California, United States
• Washington University School of Medicine Healthy Mind Lab — St Louis, Missouri, United States
• Columbia University Adult and Late Life Depression Clinic — New York, New York, United States
• UPMC Late-Life Depression, Evaluation, Prevention, and Treatment Program — Pittsburgh, Pennsylvania, United States
• Centre for Addiction and Mental Health — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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