Neuropsychologic Assessments of Dupilumab-Treated Adolescent Participants With Moderate-to-Severe Atopic Dermatitis
Completed
Conditions studied: Moderate-to-severe Atopic Dermatitis
In brief
Primary Objective: Part A * To quantify deficits in cognitive functioning in adolescents with moderate-to-severe AD, using the Conners' Continuous Performance Test 3rd Edition (CPT-3) d' T-score * To determine the entry criterion (CPT-3 d' score) for Part B Primary Objective: Part B * To measure changes in cognitive functioning in adolescents with moderate-to-severe AD treated with dupilumab Secondary Objectives * To evaluate the relationship of cognitive and sensory functioning with severity of AD in adolescent AD patients * To evaluate the relationship between changes in AD severity and changes in cognitive and sensory functioning scores following treatment with dupilumab (Part B only).
Key facts
- Study ID
- NCT05203380
- Run by
- Regeneron Pharmaceuticals
- People needed
- 45
- Starts
- 2022-01-27
- Expected to finish
- 2023-03-10
- Last updated by the study team
- 2023-09-08
Who can join
Age: 12 and older, up to 17. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Clinical Research Center of Alabama, LLC — Birmingham, Alabama, United States
- Arizona Allergy & Immunology Research — Gilbert, Arizona, United States
- Pediatric Skin Research, LLC — Coral Gables, Florida, United States
- Skin Research of South Florida, LLC — Miami, Florida, United States
- Skin Care Physicians of Georgia — Macon, Georgia, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- DermAssociates, LLC — Rockville, Maryland, United States
- National Allergy and Asthma Research, LLC — North Charleston, South Carolina, United States
- Texas Dermatology and Laser Specialists — San Antonio, Texas, United States
- Virginia Clinical Research, Inc. — Norfolk, Virginia, United States
Full record on ClinicalTrials.gov
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