Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Recruiting now
Conditions studied: Cerebral Palsy, Chronic Pain
In brief
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.
Key facts
- Study ID
- NCT05197946
- Run by
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
- People needed
- 300
- Starts
- 2018-12-04
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-06-29
Who can join
Age: 8 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Individual 8+ years of age
- Diagnosis of cerebral palsy
You may not qualify if…
- None
- Neurotypical participants: (Survey-only):
- Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
- Exclusion Criteria:
- Clinically-significant neurologic or developmental diagnosis
- Participants with CP (Survey and MRI):
- Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
- Diagnosis of cerebral palsy
- Clinical imaging demonstrating isolated periventricular white matter injury
- Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury
- Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI
- Exclusion Criteria:
- None
- Neurotypical participants (Survey and MRI):
- Inclusion Criteria:
- Individual 8+ years of age
- Adult subject able to indicate understanding and affirmative consent
- Able to lie still in scanner for 1.5 hours and be able to have MRI
- Exclusion Criteria:
- Clinically-significant neurologic or developmental diagnosis
Where it is running
- F.M. Kirby Center — Baltimore, Maryland, United States (enrolling)
- Mt. Washington Pediatric Hospital — Baltimore, Maryland, United States (enrolling)
- Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)
- Kennedy Krieger Institute — Baltimore, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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