Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
Recruiting now
Conditions studied: Cholestasis of Pregnancy
In brief
This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP). If so, it would suggest the potential benefit of immunomodulatory therapeutics.
Key facts
- Study ID
- NCT05197387
- Run by
- University Hospital, Brest
- People needed
- 322
- Starts
- 2022-06-21
- Expected to finish
- 2025-06-22
- Last updated by the study team
- 2024-10-16
Who can join
Age: 18 and older, up to 60. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Adult pregnant woman with singleton
- For cases: diagnosis of intrahepatic cholestasis of pregnancy For controls: no diagnosis of ICP
You may not qualify if…
- Women under 18 years old
- Women under legal protection
- Gemellar pregnancies
- Delivery before 22 Weeks of gestation
- Medical termination of pregnancy
- Acute chorioamniotitis, in particular those due to the following pathogens: toxoplasmosis, rubella, CMV, herpes virus
- Premature rupture of membranes <37SA
- Women infected by covid-19 in the month before delivery
Where it is running
- CHU de Tours — Tours, France (enrolling)
- Polyclinique KERAUDREN — Brest, France (enrolling)
- CHU de Brest — Brest, France (enrolling)
- CHU de Caen — Caen, France (enrolling)
- CH de Chambery — Chambéry, France (enrolling)
- CH Bretagne Sud — Lorient, France (enrolling)
- CHU Nantes — Nantes, France (enrolling)
- CH de Quimper — Quimper, France (enrolling)
- CHU de Rennes — Rennes, France (enrolling)
- CH St Brieuc — Saint-Brieuc, France (enrolling)
- CHU Angers — Angers, France
Full record on ClinicalTrials.gov
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