4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
Recruiting now · Phase 1/Phase 2
Conditions studied: Neovascular (Wet) Age-Related Macular Degeneration
In brief
Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment. Substudies will evaluate the safety and tolerability of 4D-150 contralateral eye dosing and characterize vector shedding.
Key facts
- Study ID
- NCT05197270
- Run by
- 4D Molecular Therapeutics
- People needed
- 215
- Starts
- 2021-12-09
- Expected to finish
- 2031-01-01
- Last updated by the study team
- 2026-02-12
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Emanuelli Research and Development Center, LLC — Arecibo, Puerto Rico, Puerto Rico (enrolling)
- California Retina Consultants — Oxnard, California, United States (enrolling)
- Retinal Consultants Medical Group — Sacramento, California, United States (enrolling)
- Colorado Retina Associates — Lakewood, Colorado, United States (enrolling)
- Palmetto Retina Center, LLC — West Columbia, South Carolina, United States (enrolling)
- Tennessee Retina — Nashville, Tennessee, United States (enrolling)
- Austin Clinical Research — Austin, Texas, United States (enrolling)
- Valley Retina Institute, PA — McAllen, Texas, United States (enrolling)
- Barnet Delaney Perkins Eye Center — Phoenix, Arizona, United States (enrolling)
- Vitreo Retinal Associates — Gainesville, Florida, United States (enrolling)
- Florida Eye Associates — Melbourne, Florida, United States (enrolling)
- Retinal Specialty Institute — Pensacola, Florida, United States (enrolling)
- Retina Vitreous Associates of Florida — Tampa, Florida, United States (enrolling)
- University Retina and Macula Associates — Oak Forest, Illinois, United States (enrolling)
- Retina Partners Midwest — Carmel, Indiana, United States (enrolling)
- Cumberland Valley Retina Consultants — Hagerstown, Maryland, United States (enrolling)
- Ophthalmic Consultants of Boston & Boston Eye Surgery and Laser Center — Boston, Massachusetts, United States (enrolling)
- Sierra Eye Associates — Reno, Nevada, United States (enrolling)
- Verum Research, LLC — Eugene, Oregon, United States (enrolling)
- Mid Atlantic Retina — Bethlehem, Pennsylvania, United States (enrolling)
- Rand Eye Institute — Deerfield Beach, Florida, United States
- Retina Vitreous Consultants, LLP DBA Retina Group of Florida — Fort Lauderdale, Florida, United States
- Western Carolina Retinal Associates — Asheville, North Carolina, United States
- Retina Consultants of Texas — The Woodlands, Texas, United States
- Pacific Northwest Retina LLC — Bellevue, Washington, United States
Full record on ClinicalTrials.gov
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