Role of the Protein Matrix in the Anabolic Response to a Ground Beef Patty as Opposed to the Impossible (Vegi-) Burger

Completed · Not applicable

Conditions studied: Protein Metabolism

In brief

Several of the investigator's recent studies have shown that all dietary proteins are not equal when it comes to making proteins in human bodies. Generally, foods made from animal muscle tissue are much more efficient at making new proteins in the body that those from plant sources. This study will measure the amount of protein growth in participants after consuming either one beef patty, one vegi-burger, or two vegi-burgers. By using stable isotope infusions and collecting blood and leg muscle samples, the investigator's lab can determine the rate of muscle metabolism that happens after a participant eats a protein-containing food. The investigator wants to determine if the vegi-burger is as efficient as the beef patty at creating proteins in a participants. The investigator will measure this metabolism over a 10-hour period, with the food being eaten at the 4 hour mark. The investigator plans to perform this procedure on up to 8 participants per food option (24 total).

Key facts

Study ID

NCT05197140

Run by

University of Arkansas

People needed

33

Starts

2022-05-01

Expected to finish

2022-11-03

Last updated by the study team

2024-08-05

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 18 - 40 yrs.
• Body Mass Index of 20-32 inclusive

You may not qualify if…

• Unwilling to eat animal proteins
• History of diabetes that requires medication for control of blood glucose
• History of malignancy or chemo/radiation therapy in the 6 months prior to enrollment
• History of gastrointestinal bypass/reduction surgery (Lapband, gastric sleeve, etc.)
• Pregnant females
• Hemoglobin less than 12 g/dL at screening
• Platelets less than 150,000 at screening
• Subjects who cannot refrain from using protein or amino acid supplements for 7 days prior to Visit 3
• Concomitant use of oral or injectable corticosteroids
• Concomitant use of testosterone, IGF-1, or similar anabolic agent
• Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician

Where it is running

• UAMS Center on Aging — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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