Neurostimulation for the Treatment of Post-Stroke Aphasia

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Post-stroke Aphasia

In brief

The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.

Key facts

Study ID

NCT05194566

Run by

QVITI S.A.

People needed

64

Starts

2023-09-06

Expected to finish

2026-12-01

Last updated by the study team

2026-02-18

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist).
• presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination);
• chronic stage of the disease - time since the stroke occurred over 6 months.
• ability to achieve an accuracy in the Naming Task of 10-60%.
• 18-80 years
• right-handedness before the stroke.
• ability to give informed written consent.
• fluency in English.

You may not qualify if…

• severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command.
• presence of metal implants in the skull.
• presence of major untreated or unstable psychiatric disease.
• history of epilepsy or seizures.
• ongoing medication that increases the risk of epileptic seizures.
• presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted).
• history of speech, language, hearing, or intellectual disability during childhood.
• pregnancy (based on declarations)
• Exclusion criteria during the trial:
• high intolerance to stimulation.
• occurrence of an epileptic seizure.
• other previously absent neurological or mental symptoms
• Withdrawal criteria:
• high intolerance to stimulation (participants experience severe discomfort during stimulation);
• occurrence of an epileptic seizure;
• other previously absent neurological, physical or mental symptoms.

Where it is running

• Think & Speak Lab at Shirley Ryan AbilityLab — Chicago, Illinois, United States (enrolling)
• Abilities Research Center at Mount Sinai — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.