Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function

Withdrawn before enrolling · Not applicable

Conditions studied: Depressive Disorder, Major

In brief

The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit brain activity in healthy volunteers.

Key facts

Study ID

NCT05194332

Run by

The University of Texas Health Science Center, Houston

People needed

0

Starts

2026-01-01

Expected to finish

2028-01-01

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Must be right-handed
• Must be illicit drug-free at the time of scanning as appropriate (verified by negative urine drug screen)
• Must be healthy (without medical, neurological, psychiatric illness)
• Must be psychotropic medication free (≥ 14 days)

You may not qualify if…

• Must not be a smoker
• Females must not be pregnant or nursing
• Must not suffer from claustrophobia
• Must not meet exclusion criteria for MRI scanning (i.e., non-fixed magnetizable objects)
• Must not have ongoing, chronic, or relapsing/remitting medical, psychiatric,or neurological illness as determined by a combination of history, medical record, and/or examination.

Where it is running

• The University of Texas Health Science Center at Houston — Houston, Texas, United States

Full record on ClinicalTrials.gov

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