Prospective Phenotyping for Genetic Subtypes of Early-onset Atrial Fibrillation
Completed
Conditions studied: Atrial Fibrillation
In brief
This is a prospective, case-control study that seeks to learn about the role of genetics in early onset atrial fibrillation (AF) and if genetic testing can be used to improve how the investigators treat atrial fibrillation. The study will enroll 225 participants. Eligible participants will have undergone sequencing for arrhythmia and cardiomyopathy (CM) genes. Based on those results, participants will be recruited for an outpatient research visit with testing that includes cardiac MRI, rest/stress/signal-averaged ECGs, and cardiac monitoring. If an inherited arrhythmia/CM syndrome is diagnosed, guideline-directed changes to medical care will be recommended.
Key facts
- Study ID
- NCT05190679
- Run by
- Vanderbilt University Medical Center
- People needed
- 155
- Starts
- 2022-04-27
- Expected to finish
- 2026-03-03
- Last updated by the study team
- 2026-05-06
Who can join
Age: 15 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Minors >15 years
- Adult > 18 years
- Able to provide written informed consent
- Previously enrolled in the Vanderbilt Atrial Fibrillation Registry (IVR#020669)
- Atrial Fibrillation Ablation Registry (IRB#110881)
- Early-onset Atrial Fibrillation Registry (IRB#201666)
- Underwent whole genome sequencing/whole exome sequencing or clinical genetic testing and based on those results meets the genetic criteria for cases and controls as defined as a Cardiomyopathy (CM) Rare Variant (P/LP rare variant in CM gene, Arrhythmia Rare Variant (P/LP rare variant in arrhythmia gene), or a Control (no rare variant in CM, arrhythmia, or other Atrial Fibrillation gene).
- Diagnosis of Atrial Fibrillation prior to age of 65 (</=65)
You may not qualify if…
- Pregnant women
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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