Cannabidiol and Focus Study (CBD-Focus)

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy

In brief

Cannabidiol (CBD), a non-psychoactive hemp derivative, is an attractive therapeutic target, and is most supported by the scientific community as an antiepileptic, anxiolytic, and antipsychotic. Additionally, CBD may cause alterations in aspects of health and fitness, fatigue, stress, calmness, quality of life, cognitive function, ability to maintain focus, sleep quantity, and sleep quality. Cannabidiol may be associated with alterations in inflammatory response in the human body, which has implications in both healthy and diseased populations. Natural killers cells (NKC) play a vital role in maintain your body's defenses and are an essential component of your immune system. In humans, NKC contain the highest concentrations of receptors associated with the endocannabinoid system and CBD. Human models have demonstrated that CBD use increases the percentage of NKC in peripheral blood. However, similar models found that CBD administration inhibits markers of NKC cytotoxic function, a beneficial cellular mechanism used to prevent malignant cell transformation and viral infection. The overarching goal of this investigation is to determine the effects of an 8-week CBD intervention on measures of fatigue, stress, calmness, quality of life, cognitive function, focus, health and fitness, and sleep quantity, and sleep quality. In addition, this study will explore a potential CBD mechanism of action with a focus on biomarkers of neural health, inflammation, liver health, kidney health, as well as NKC number and function.

Key facts

Study ID

NCT05189275

Run by

University of Northern Colorado

People needed

100

Starts

2022-01-10

Expected to finish

2022-12-31

Last updated by the study team

2023-09-26

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Currently completing at least 150 minutes of moderate to vigorous physical activity per week
• Have a body mass index under 29.9
• No significant physical or mental health (without the presence of chronic depression or anxiety) conditions
• No presence or past diagnosis of eating disorders

You may not qualify if…

• Subjects may not have an allergy to soy.
• All study subjects must also be free of cannabis product use or regular high doses of antioxidants for the previous 8 weeks.
• Participants receive a $200 Visa Gift Card after the last study visit is completed.

Where it is running

• University Of Northern Colorado — Greeley, Colorado, United States

Full record on ClinicalTrials.gov

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