Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM
Completed · Phase 3 · Has a placebo group
Conditions studied: Obstructive Hypertrophic Cardiomyopathy (oHCM)
In brief
The purpose of this study is to evaluate the efficacy and safety of aficamten (CK-3773274) versus placebo in adults with symptomatic hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract obstruction.
Key facts
- Study ID
- NCT05186818
- Run by
- Cytokinetics
- People needed
- 282
- Starts
- 2022-02-01
- Expected to finish
- 2023-12-18
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Ziv Medical Center — Safed, Israel
- Alaska Heart and Vascular Institute — Anchorage, Alaska, United States
- UC San Diego Health - Sulpizio Cardiovascular Center — La Jolla, California, United States
- Cedars-Sinai Medical Center - Smidt Heart Institute Clinic — Los Angeles, California, United States
- University of California San Francisco — San Francisco, California, United States
- Stanford University Hospital — Stanford, California, United States
- Yale School of Medicine — New Haven, Connecticut, United States
- Yale University School of Medicine — New Haven, Connecticut, United States
- MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
- Holy Cross Hospital / Cardiology Associates — Fort Lauderdale, Florida, United States
- Mayo Clinic Florida — Jacksonville, Florida, United States
- Emory Clinic — Atlanta, Georgia, United States
- Piedmont Fayette Hospital — Fayetteville, Georgia, United States
- Northwestern University — Chicago, Illinois, United States
- University of Iowa — Iowa City, Iowa, United States
- MedStar Medical Group Cardiology at Union Memorial — Baltimore, Maryland, United States
- Medstar Franklin Square Medical Center — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
- Lahey Hospital & Medical Center — Burlington, Massachusetts, United States
- Michigan Medicine — Ann Arbor, Michigan, United States
- Henry Ford Medical Center — Detroit, Michigan, United States
- Spectrum Health Medical Group Cardiovascular Medicine — Grand Rapids, Michigan, United States
- M Health Fairview University of Minnesota Medical Center - East Bank — Minneapolis, Minnesota, United States
- Cleveland Clinic — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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