ERAS® Guidelines Validation of CRS With or Without HIPEC

Status unconfirmed

Conditions studied: Peritoneal Diseases

In brief

Enhanced recovery after surgery (ERAS®) pathways have been shown to considerably reduce complications, length of stay and costs after most of surgical procedures by standardised application of best evidence-based perioperative care. Recently an international panel of expert have succeeded to elaborate dedicated recommendations for cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC) in a two-part series of guidelines based on expert consensus (Hübner et al., EJSO, 2020). The aim of this prospective validation study was therefore to study acceptance, feasibility and clinical results of these guidelines in clinical practice. Hypothesis of the study: Introduction of ERAS® guidelines is feasible and safe. Increasing compliance with ERAS® guidelines (after implementation) will improve recovery and early clinical outcomes of patients undergoing CRS/HIPEC.

Key facts

Study ID

NCT05185791

Run by

Hospices Civils de Lyon

People needed

288

Starts

2021-10-01

Expected to finish

2022-08-31

Last updated by the study team

2022-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults female and male patients (> 18 year-old)
• Peritoneal cancer from colorectal, ovarian, gastric, appendix origin and primitive peritoneal cancer (peritoneal mesothelioma)
• Multidisciplinary team meeting validation for CRS/HIPEC
• Informed and signed surgical consent

You may not qualify if…

• Patients without peritoneal cancer
• Patients with peritoneal cancer and extended extraperitoneal metastases contraindicating for CRS with or without HIPEC
• No informed consent signed

Where it is running

• University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
• University of Calgary, Arnie Charbonneau Cancer Institute — Calgary, Alberta, Canada (enrolling)
• Lausanne University Hospital — Lausanne, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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