Sleep and Circadian Mechanisms in Hypertension

Recruiting now · Not applicable

Conditions studied: Hypertension, Cardiovascular Diseases, Cardiovascular Risk Factors, Circadian Rhythms, Sleep

In brief

This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).

Key facts

Study ID

NCT05184933

Run by

Oregon Health and Science University

People needed

32

Starts

2022-08-04

Expected to finish

2029-03-30

Last updated by the study team

2026-02-11

Who can join

Age: 25 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 25-64
• BMI 18.5-42kg/m2
• Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)

You may not qualify if…

• Over 5 pack-years of smoking;
• Prior shift work within 12 months prior to the study;
• Travel greater than three time zones for at least 3 months;
• History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
• Acute or chronic diseases (except hypertension) that may affect outcome measures;
• History of psychological conditions;
• Sleep disorders, like severe sleep apnea, insomnia, etc.;
• Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
• History of Illicit drug use and alcohol dependency;
• 30 days free of cannabis use prior to the study;
• Pregnancy;
• Upper cut-off of 160/100 mmHg for BP

Where it is running

• Oregon Health and Science University — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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