Comparing Two Ways to Manage Head and Neck Lymphedema

Running, not enrolling · Not applicable

Conditions studied: Head and Neck Cancer, Lymphedema

In brief

This randomized clinical trial aims to compare clinic-based CDT and home-based (a hybrid model) CDT on changes in the severity of lymphedema, symptom burden, functional status, and healthcare utilization in HNC survivors with lymphedema.

Key facts

Study ID

NCT05182229

Run by

Abramson Cancer Center at Penn Medicine

People needed

240

Starts

2022-03-11

Expected to finish

2027-06-30

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• >18 years of age
• <=24 months post-HNC treatment
• Diagnosis of head and neck lymphedema and referral by their oncology providers
• Able to perform self-manual lymphatic drainage
• Having an electronic device (a computer, tablet, iPad, laptop, or smartphone) and internet access at home

You may not qualify if…

• Active infection in soft tissues in the head and neck region
• History of moderate or severe carotid artery occlusion
• Significantly severe lymphedema (e.g., severe periorbital swelling)
• Conditions impacting the safe delivery of lymphedema therapy

Where it is running

• Jefferson Cherry Hospital Jefferson Health — Cherry Hill, New Jersey, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Jefferson Health — Philadelphia, Pennsylvania, United States
• Jefferson Torresdale Hospital Jefferson Health — Philadelphia, Pennsylvania, United States
• Temple University Hospital and Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• Asplundh Cancer Pavilion Jefferson Health — Willow Grove, Pennsylvania, United States

Full record on ClinicalTrials.gov

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