Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
Recruiting now · Phase 2
Conditions studied: Alcohol Use Disorder (AUD), Nicotine Use Disorder
In brief
Using a randomized controlled trial (RCT), the goal of this study is to evaluate the ability of evidence based behavioral treatment (contingency management: CM) to significantly decrease alcohol use and cigarette smoking among treatment-seeking smokers with an alcohol use disorder (AUD) who have initiated pharmacotherapy (varenicline; VC) for smoking cessation.
Key facts
- Study ID
- NCT05181891
- Run by
- Washington State University
- People needed
- 205
- Starts
- 2022-07-11
- Expected to finish
- 2027-05-01
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 4 or more standard drinks on the same occasion for women (5 or more standard drinks on the same occasion for men) on at least 4 occasions in the prior 30 days
- Seeking AUD treatment
- Seeking smoking cessation treatment
- Aged 18+ years
- DSM-5 diagnosis of AUD
- Currently smoking daily according to PhenX Smoking Status (100 or more lifetime cigarettes plus current daily smoking)
- Ability to read and speak English
- Ability to provide written informed consent
- Breath alcohol of 0.00 during informed consent
- Provision of at least 1 EtG-positive urine test at any time during the induction period and at least one COT-positive urine test at any time during the induction period; and
- Attended at least 4 of 6 possible visits during the induction period.
You may not qualify if…
- Significant risk of dangerous alcohol withdrawal, defined as a history of alcohol detoxification or seizure in the last 12 months and expression of concern by the participant about dangerous withdrawal
- Currently receiving any pharmacotherapy for alcohol
- Currently receiving any pharmacotherapy for smoking
- No suicide attempt in the last 20 years and
- Any other medical (discernable by initial blood tests) or psychiatric condition that Drs. Layton or Rodin determine would compromise safe participation.
Where it is running
- Washington State University — Spokane, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
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