Imaging Brain Fluids During Breathing
Running, not enrolling · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.
Key facts
- Study ID
- NCT05180981
- Run by
- Boston University Charles River Campus
- People needed
- 81
- Starts
- 2022-01-18
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-07-27
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult age 18-70 years
You may not qualify if…
- No ferrous metal implanted in head or body
- No history of major head trauma
- No neurological or psychiatric disorder
- Not using medication that affects brain function
- No implanted electronic devices (e.g. pacemaker)
- No implant that poses an MR contraindication
- Not pregnant, suspect they are pregnant, or seeking to become pregnant
- Not claustrophobic
- No piercings or jewelry that cannot be removed
- Does not weigh more than 250 pounds
- Normal or contact-corrected normal vision
- Exclusion for transcutaneous vagus nerve stimulation (tVNS) arm:
- Conditions of skin or anatomy that affect left auricle or forehead skin and could impact placement of electrodes for tVNS or forehead stimulation
- Diagnosis of significant cardiovascular or cerebrovascular disease [e.g. congestive heart failure, stroke, cardiac conduction disorders (including: bundle branch block, heart block, long Q-T syndrome), history of asystole or non-sustained ventricular tachycardia.
- Bradycardia (defined as resting heart rate <50 bpm)
- Hypotension defined as blood pressure <90/60 mmHg
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Boston University - Charles River Campus — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.