RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.

Completed

Conditions studied: Severe Eosinophilic Asthma, Nasal Polyps

In brief

The purpose of this observational study is to describe the population of patients with SEA + NP who have been prescribed FASENRA and assess available clinical outcomes for both NP and asthma.

Key facts

Study ID

NCT05180357

Run by

AstraZeneca

People needed

273

Starts

2021-11-23

Expected to finish

2022-10-28

Last updated by the study team

2023-04-19

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current or previous treatment with benralizumab for SEA
• Physician-confirmed diagnosis and evaluation of NP using NPS and/or SNOT-22 before and after first benralizumab injection
• Patients who have follow-up period of at least 5 months from first benralizumab injection or at least 4 consecutive injections of benralizumab
• Able to provide signed informed consent (if required based on local guidelines)

You may not qualify if…

• Patient on any other biologic during the 12 months prior to treatment with benralizumab
• Previously or currently receiving any biologics for the treatment of asthma or NP in a clinical trial. This exclusion criteria does not apply to patients that received biologic treatment from openlabel one-arm interventional studies that provided biologic treatment as part of standard of care (according to approved labelling in that country).

Where it is running

• Research Site — Centennial, Colorado, United States
• Research Site — Denver, Colorado, United States
• Research Site — Glendale, New York, United States
• Research Site — New York, New York, United States
• Research Site — Rochester, New York, United States
• Research Site — The Bronx, New York, United States
• Research Site — Philadelphia, Pennsylvania, United States
• Research Site — Norfolk, Virginia, United States
• Research Site — Lyon, France
• Research Site — Marseille, France
• Research Site — Montpellier, France
• Research Site — Nantes, France
• Research Site — Strasbourg, France
• Research Site — Lübeck, Germany
• Research Site — Wiesbaden, Germany
• Research Site — Catania, Italy
• Research Site — Catanzaro, Italy
• Research Site — Florence, Italy
• Research Site — Milan, Italy
• Research Site — Modena, Italy
• Research Site — Monserrato, Italy
• Research Site — Naples, Italy
• Research Site — Orbassano, Italy
• Research Site — Ragusa, Italy
• Research Site — Rome, Italy

Full record on ClinicalTrials.gov

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