Transcutaneous Stimulation in Spinal Cord Injury
Completed · Not applicable
Conditions studied: Spinal Cord Injury
In brief
Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving from a laying down position to upright; however, findings in the general population link the RAAS with remodeling and restructuring of the arterial walls. Therefore, intervention to stabilize and normalize blood pressure should be a priority in individuals with spinal cord injury who have low blood pressure. Advances in stimulation on the skin of the spinal cord offer an approach to restore cardiovascular control and improve blood pressure regulation; however, electrode placement and stimulation parameters needed to increase blood pressure are not well understood. Therefore, the aim of the study is to identify placement of electrodes on the skin, and frequency and amplitude of the stimulation to regulate blood pressure.
Key facts
- Study ID
- NCT05180227
- Run by
- VA Office of Research and Development
- People needed
- 10
- Starts
- 2022-06-01
- Expected to finish
- 2024-07-31
- Last updated by the study team
- 2025-09-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- above the age of 18 years old
- individuals with traumatic spinal cord injuries at or above T6
- duration of injury if more than 1 year
- non-ambulatory
- American spinal injury association scale A, B or C
- able to provide consent
- non-ventilator
- hypotensive (males: systolic blood pressure less than 110 mmHg and/or diastolic blood pressure less than 70 mmHg; females: systolic blood pressure less than 100 mmHg and/or diastolic blood pressure less than 70 mmHg)
You may not qualify if…
- acute illness or infection
- documented history of controlled or uncontrolled diabetes
- any other neurological disease other than spinal cord injury
- cardiovascular disease (coronary artery disease, congestive heart failure, peripheral artery disease, stroke)
- present of history of thrombosis in the last 12 months, severe contractures
- pregnant
Where it is running
- James J. Peters VA Medical Center, Bronx, NY — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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