Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2)

Completed · Not applicable · Has a placebo group

Conditions studied: COVID-19, Coronavirus Infection, SARS CoV 2 Infection

In brief

Randomized, double-blind prospective trial to test the efficacy of therapeutic, antiseptic mouth rinses to inactivate severe acute respiratory syndrome coronavirus (SARS-CoV-2) in saliva of COVID-19 positive patients aged 18-65 years old. All mouthrinses are commercially available and will be used according to on-label instructions. Patients will be randomized to a mouthrinse and will be asked to give a saliva sample immediately before and after a one minute mouthwash. Saliva samples will be collected from patients at 15 minute intervals thereafter up to an hour (15, 30, 45 and 60 minutes). The samples will be stored and used for real-time reverse transcription polymerase chain reaction (RT-PCR) detection of viral SARS-CoV-2 RNA and viral infectivity assays. Patients will also complete a short-survey on the taste and experience of using the mouthwash. This study involves 150 subject participants and one, 75-90 minute visit.

Key facts

Study ID
NCT05178173
Run by
University of North Carolina, Chapel Hill
People needed
230
Starts
2022-01-20
Expected to finish
2023-07-12
Last updated by the study team
2024-09-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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