Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

Completed · Not applicable

Conditions studied: Cigarette Smoking, Nicotine Vaping

In brief

This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.

Key facts

Study ID

NCT05177848

Run by

Virginia Polytechnic Institute and State University

People needed

60

Starts

2022-06-29

Expected to finish

2023-06-07

Last updated by the study team

2025-01-30

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide informed consent
• Be at least 21 years of age or older
• Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm)
• Stable tobacco use patterns for at least three months
• Be willing to sample NVPs, HTPs, and NPPs
• For exclusive cigarette smokers: smoke at least 10 cigarettes daily and do not use NVPs regularly (no more than 9 times in the last month)
• For dual cigarette/NVP users: smoke at least 5 cigarettes daily and use NVPs for at least 3 times in a week (report use of closed nicotine salt system)

You may not qualify if…

• Have plans to move out of the area
• Have a serious or unstable physical or mental health condition
• Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement
• Report concrete, immediate plans to alter/quit using their usual nicotine products at the beginning of the study

Where it is running

• Fralin Biomedical Research Institute — Roanoke, Virginia, United States

Full record on ClinicalTrials.gov

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