The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia
Completed · Has a placebo group
Conditions studied: Alzheimer Disease, Dementia, Prescribing, Off-Label
In brief
This study aims to analyze how warning letters sent to physicians prescribing high levels of the antipsychotic quetiapine affected the health and quality of life of their patients with dementia. Using a randomized controlled trial conducted by the Centers for Medicare and Medicaid Services (CMS) in 2015, this secondary study looks at the effects of potential de-prescribing of antipsychotics by study physicians induced by the letters. The central question is whether the intervention led to better health and quality of life outcomes by encouraging more guideline-concordant care and whether changes in physicians' prescription behavior caused unintended harms.
Key facts
- Study ID
- NCT05172687
- Run by
- Columbia University
- People needed
- 336460
- Starts
- 2015-04-01
- Expected to finish
- 2018-12-31
- Last updated by the study team
- 2024-02-13
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Fully enrolled in Fee-For-Service Medicare Parts A, B, and D
- For nursing home patients: Residing in a nursing home and has a usable nursing home assessment to measure outcomes
- For community-dwelling patients: Not residing in a nursing home
- Has Alzheimer's or dementia related disease diagnosis
- Attributed to study physician (see study population description)
You may not qualify if…
- Died during 90 day period used to attribute patient to physician
- For nursing home patients: Short-stay nursing facility patient
Where it is running
- Harvard T.H. Chan School of Public Health — Boston, Massachusetts, United States
- National Bureau of Economic Research — Cambridge, Massachusetts, United States
- Columbia University — New York, New York, United States
Full record on ClinicalTrials.gov
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