Noninvasive Monitoring of Cerebral Blood Flow Autoregulation

Completed

Conditions studied: Intracranial Pressure Increase, Cerebral Edema

In brief

Rheoencephalography (REG) shows promise as a method for noninvasive neuromonitoring, because it reflects cerebrovascular reactivity. This protocol will study clinical and technical conditions required to use REG. Additionally, our goal is to study noninvasive peripheral bioimpedance pulse waveforms in order to substitute invasive SAP. A previous study demonstrated that REG can be used to detect spreading depolarization (SD), the early sign of brain metabolic disturbance. SD can be measured invasively with DC EEG amplifiers only. Our goal is to create an automatic notification function for REG monitoring indicating change of clinical conditions.

Key facts

Study ID

NCT05170295

Run by

Ochsner Health System

People needed

14

Starts

2018-04-18

Expected to finish

2021-04-28

Last updated by the study team

2021-12-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Intact fronto-temporal area
• Intact lower arm area
• Clinical suspicion of elevated intracranial pressure

You may not qualify if…

• N/A

Where it is running

• Ochsner Health System — New Orleans, Louisiana, United States

Full record on ClinicalTrials.gov

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