Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women

Status unconfirmed

Conditions studied: Coronary Artery Disease, Genetic Predisposition to Disease

In brief

The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000). DNA from a blood sample will be genotyped for millions of genetic risk variants for CAD by Baylor College of Medicine Human Genome Sequencing Center Clinical Laboratory (HGSC-CL) in a CLIA-approved laboratory. The overall objective after 2 years is to determine if genetic screening for risk of CAD in asymptomatic men and women has the discriminatory power to detect those at highest risk who would potentially benefit most from appropriate primary prevention. It will also determine whether the GRS is appropriate for different ethnic and race groups such as Hispanics, African Americans and Whites, and to what extent those individuals knowing that they are at higher risk, are more likely to seek further advice on management of the risks (either through changes in lifestyle or therapy).

Key facts

Study ID

NCT05169840

Run by

St. Joseph's Hospital and Medical Center, Phoenix

People needed

2000

Starts

2021-08-23

Expected to finish

2024-06-15

Last updated by the study team

2023-11-24

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males 40 to 60 years of age
• Females 40 to 60 years of age
• No known cardiovascular disease
• Willing and able to sign consent

You may not qualify if…

• Prisoners
• Prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
• Known ischemia on non-invasive testing
• Ischemic cerebrovascular event
• Peripheral arterial disease

Where it is running

• Chandler Regional Medical Center — Chandler, Arizona, United States (enrolling)
• Mercy Gilbert Medical Center — Gilbert, Arizona, United States (enrolling)
• St Joseph's Hospital and Medical Center — Phoenix, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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