Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction

Recruiting now

Conditions studied: Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility, Habitual Abortion, Recurrent Miscarriage, Recurrent Spontaneous Abortion

In brief

A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including recurrent implantation failure (RIF) after assisted reproductive technology (ART) (including IVF, ICSI and FET), recurrent pregnancy loss (RPL) after spontaneous conception, and RPL after ART.

Key facts

Study ID

NCT05169541

Run by

Aalborg University Hospital

People needed

500

Starts

2016-01-01

Expected to finish

2026-11-30

Last updated by the study team

2025-11-24

Who can join

Age: 18 and older, up to 41. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• fulfil one of the following:
• 3 consecutive pregnancy losses after spontaneous conception
• 3 consecutive pregnancy losses after assisted reproductive technology treatment (ART) including IVF, ICSI and FET
• 3 failed embryo transfers characterized by no achieved pregnancy (after 3 cycles with minimum 1 embryo transfer of a good-quality embryo in each cycle.)

You may not qualify if…

• Age <18 or >45 years
• AMH <4.0 pmol/l unless donor egg in previous cycles
• Significant uterine malformation
• Known endometrial pathologies including intrauterine endometriosis, adenomyosis, hyperplasia or polyps
• Known chromosomal abnormalities
• Pregnancy >9 weeks of gestation at the time collecting the blood sample

Where it is running

• Aagaard Klinik — Aarhus, Denmark (enrolling)

Full record on ClinicalTrials.gov

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