The Oxford Risk Factors And Non-Invasive Imaging Study

Recruiting now

Conditions studied: Cardiovascular Diseases, Cardiovascular Risk Factors

In brief

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Key facts

Study ID

NCT05169333

Run by

University of Oxford

People needed

250000

Starts

2016-02-23

Expected to finish

2030-02-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion Criteria for study Arms 1, 2 and 3:
• Participant is willing and able to give informed consent for participation in the study.
• Male or Female, aged 18 -99 years.
• Inclusion Criteria for study Arm 4:
• Male or Female, aged 18 -99 years.

You may not qualify if…

• Exclusion Criteria for Study Arms 1, 2 and 3:
• Unable or unwilling to consent
• Active cancer
• Exclusion Criteria for Study Arm 4:
• Participation in Study Arms 1, 2 or 3
• Existing opt-out from use of data for research purposes

Where it is running

• Heart and Lung Centre, New Cross Hospital — Wolverhampton, United Kingdom (enrolling)
• Yale University, School of Medicine — New Haven, Connecticut, United States (enrolling)
• Bridging Medical Silos — Tampa, Florida, United States (enrolling)
• Emory University — Atlanta, Georgia, United States (enrolling)
• Midwest Heart & Vascular Specialists LLC — Kansas City, Kansas, United States (enrolling)
• St Luke's Hospital — Kansas City, Kansas, United States (enrolling)
• NIH National Heart, Lunch, and Blood Institute — Bethesda, Maryland, United States (enrolling)
• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Cleveland Clinic — Cleveland, Ohio, United States (enrolling)
• UT Southwestern Medical Center — Dallas, Texas, United States (enrolling)
• Brooke Army Medical Center (BAMC) — San Antonio, Texas, United States (enrolling)
• University of Virginia — Charlottesville, Virginia, United States (enrolling)
• Leeds Teaching Hospitals NHS Trust — Leeds, United Kingdom (enrolling)
• University Hosptials of Leicester NHS Trust — Leicester, United Kingdom (enrolling)
• Barts Health NHS Trust — London, United Kingdom (enrolling)
• Guy's and St Thomas' NHS Foundation Trust — London, United Kingdom (enrolling)
• Royal Brompton and Harefield Hospitals — London, United Kingdom (enrolling)
• Milton Keynes University Hospital — Milton Keynes, United Kingdom (enrolling)
• The Newcastle Hospitals NHS Foundation Trust — Newcastle upon Tyne, United Kingdom (enrolling)
• Oxford University Hospitals NHS Foundation Trust — Oxford, United Kingdom (enrolling)
• Valleywise Health — Phoenix, Arizona, United States (enrolling)
• Nicosia Polyclinic — Nicosia, Cyprus (enrolling)
• GØdstrup Regional hospital — Aarhus, Denmark (enrolling)
• Assistance Publique - Hôpitaux de Paris — Paris, France (enrolling)
• Friedrich-Alexander-Universitat Erlangen-Nurmberg — Erlangen, Germany (enrolling)

Full record on ClinicalTrials.gov

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