Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Dexmedetomidine, Postoperative Delirium

In brief

Postoperative delirium (POD) is a common surgical complication. The incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures. Many studies have shown that dexmedetomidine(DEX) may reduce the incidence of delirium in non-cardiac surgery patients and elderly patients. However, there are few studies focus on the effect of DEX on POD in elderly patients undergoing neurosurgery. The purpose of this study was to investigate the effect of DEX on POD in in elderly patients undergoing craniotomy.

Key facts

Study ID: NCT05168280
Run by: Beijing Tiantan Hospital
People needed: 420
Starts: 2022-07-18
Expected to finish: 2025-12-30
Last updated by the study team: 2025-03-03

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients undergoing selective craniotomy.
Age ≥65 years.
Obtain written informed consent.

You may not qualify if…

Operation time less than 2 hours.
Refusal to provide written informed consent.
Cognitive impairment before surgery(mini-mental state examination, MMSE ≤ 26 or Montreal Cognitive Assessment, MoCA≤22).
Allergic to the study drug.
Body mass index ≤18 or ≥ 30 kg/m2.
History of psychotropic drugs, anticholinergic drugs, antihistamine drug and dopaminergic drugs.
History of traumatic brain injury or neurosurgery.
Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block.
Severe liver dysfunction (Child-Pugh grade C) or renal failure (requiring kidney replacement therapy).
The functional neurosurgery.

Where it is running

Beijing Tian Tan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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