Inflammation in Methamphetamine and STIs (IMSTI)
Completed · Not applicable
Conditions studied: Methamphetamine-dependence, Rectal Gonorrhea, Rectal Chlamydia
In brief
This clinical trial aims to investigate the effects of a decline in methamphetamine use on rectal inflammatory cytokine levels, substance use contexts, and HIV/STI risk behavior. This clinical trial also seeks to evaluate joint effects of methamphetamine use and rectal gonorrhea/chlamydia infection on rectal inflammatory cytokine levels. The proposed trial will consist of 40 MSM, half with rectal gonorrhea/chlamydia infection at enrollment (n=20), with methamphetamine use disorder that will receive contingency management for methamphetamine reduction. Following baseline measurement, participants will be observed over the course of 8 weeks, where participants will complete behavioral surveys, provide urine for drug testing, and rectal samples for measurement of rectal inflammatory cytokine levels.
Key facts
- Study ID
- NCT05162391
- Run by
- University of California, Los Angeles
- People needed
- 59
- Starts
- 2022-05-31
- Expected to finish
- 2026-04-15
- Last updated by the study team
- 2026-06-11
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Cisgender male
- 18 years of age or older
- Understand written and spoken English
- Condomless receptive anal intercourse in past 90 days
- Meet DSM-5 criteria for methamphetamine use disorder
- Positive urine toxicology screen for MA metabolites at study entry
- Negative rectal GC/CT screen (n=20) or Positive rectal GC and/or CT screen (n=20)
- Able to provide written informed consent and willing/able to complete study visits.
You may not qualify if…
- Reports current treatment for another substance use disorder
- Positive test for opioids, cocaine, and/or hallucinogens
- Treatment for gonorrhea and/or chlamydia infection in past 3 months
- Presence of a condition that in the opinion of the investigator would compromise the safety of the patient or the quality of the data
Where it is running
- UCLA Vine Street Clinic — Los Angeles, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.