A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3
Stopped early · Phase 1 · Has a placebo group
Conditions studied: Spinocerebellar Ataxia Type 3
In brief
The primary objective of this study is to evaluate the safety and tolerability of multiple ascending doses of BIIB132 administered via intrathecal (IT) injection to participants with spinocerebellar ataxia type 3 (SCA3). The secondary objective of this study is to characterize the multiple-dose pharmacokinetics (PK) of BIIB132 administered via IT injection to participants with SCA3.
Key facts
- Study ID
- NCT05160558
- Run by
- Biogen
- People needed
- 8
- Starts
- 2022-02-02
- Expected to finish
- 2023-07-25
- Last updated by the study team
- 2023-08-04
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of California - Los Angeles — Los Angeles, California, United States
- University of California San Francisco — San Francisco, California, United States
- University of Florida, Center for Movement Disorders — Gainesville, Florida, United States
- Movement Disorder Center Florida — Tampa, Florida, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Washington University — St Louis, Missouri, United States
- Columbia Univeristy Medical Center — New York, New York, United States
- Pennsylvania Neurological Institute — Philadelphia, Pennsylvania, United States
- Houston Methodist Research Institute — Houston, Texas, United States
- University of Washington — Seattle, Washington, United States
- UniversitaetsklinikumTübingen Neurologische Universitätsklinik — Tübingen, Baden-Wurttemberg, Germany
- Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE) — Bonn, North Rhine-Westphalia, Germany
- Universitaetsklinikum Essen Klinik für Neurologie — Essen, North Rhine-Westphalia, Germany
- Tel Aviv Sourasky Medical Center — Tel Aviv, Israel
- Universitair Medisch Centrum Groningen (UMCG) — Groningen, Netherlands
- Radboudumc — Nijmegen, Netherlands
- Centro Hospitalar de Lisboa Norte — Lisbon, Portugal
- Centro Hospitalar do Porto — Porto, Portugal
- University College London Hospital (UCLH) — London, Greater London, United Kingdom
- Churchill Hospital — Oxford, Oxfordshire, United Kingdom
Full record on ClinicalTrials.gov
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