The Home Blood Pressure (BP) Trial
Completed · Not applicable
Conditions studied: End Stage Renal Disease on Dialysis
In brief
The main study will be a two arm 10-month, cross-over randomized controlled trial of 200 participants treated with end-stage-kidney-disease treated with in-center hemodialysis in the Seattle and San Francisco area comparing a strategy of targeting home vs. pre-dialysis systolic blood pressure \<140 mmHg to reduce rates of intradialytic hypotension. The target systolic blood pressure of \<140 mmHg in both treatment groups will be achieved using an algorithm of dry weight adjustment and anti-hypertensive medication adjustment.
Key facts
- Study ID
- NCT05159999
- Run by
- University of Washington
- People needed
- 200
- Starts
- 2022-02-02
- Expected to finish
- 2026-07-01
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18 years or older
- Undergoing in-center, thrice weekly hemodialysis for treatment of end stage renal disease (ESRD)
- Greater than 3 months since initiation of dialysis
- No anticipated change to peritoneal dialysis or kidney transplant within 10 months
- Life expectancy greater than 10 months
- Hypertension (defined as mean pre-dialysis SBP > 140 mmHg over prior 2 weeks or taking BP medications)
- Able to obtain/measure a brachial blood pressure at dialysis and at home (e.g., no left ventricular assist device, blood pressure not been taken routinely in lower extremity at dialysis unit)
- No condition that the primary nephrologist or PIs feel precludes participation
You may not qualify if…
- Incarcerated or institutionalized (prohibits home blood pressure measurement)
- Participating in another intervention study that may affect blood pressure
- Pregnant or anticipated pregnancy or breastfeeding (as this will require increase to more than three times a week dialysis and/or preclude use of some classes of blood pressure medications)
Where it is running
- University of California San Francisco — San Francisco, California, United States
- University of Washington — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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