Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry

Starting soon

Conditions studied: Myocarditis, Premature Ventricular Contractions, Ventricular Tachycardia (VT)

In brief

To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.

Key facts

Study ID

NCT05158751

Run by

Kansas City Heart Rhythm Research Foundation

People needed

100

Starts

2026-01-01

Expected to finish

2026-05-01

Last updated by the study team

2025-09-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients > 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
• Non-sustained VT was defined as ≥3 more consecutive beats lasting <30 seconds

You may not qualify if…

• History of myocardial infarction,
• Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
• History of revascularization,
• Significant symptomatic atrial arrhythmias associated with LV dysfunction,
• Severe valvular disease,
• Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
• History of cardiac arrest,
• History of channelopathies or inherited arrhythmias.

Where it is running

• Kansas City Heart Rhythm Institute — Overland Park, Kansas, United States

Full record on ClinicalTrials.gov

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