China National Registry of Neuro-Inflammatory Diseases

Recruiting now

Conditions studied: Multiple Sclerosis, NMO Spectrum Disorder, Clinically Isolated Syndrome, CNS Demyelinating Autoimmune Diseases, Acute Disseminated Encephalomyelitis, Primay Angiitis of the Central Nervous System, Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

In brief

Central nervous system (CNS) idiopathic inflammatory demyelinating diseases (IDD) are mainly diseases caused by autoimmune factors that result in CNS demyelination damage and loss. It tends to accumulate in the brain, spinal cord and optic nerves. Multiple sclerosis (MS), clinically isolated syndrome (CIS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and acute disseminated encephalomyelitis (ADEM) are all common IDDs of the CNS. Besides, primary angiitis of the central nervous system (PACNS), autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A), etc. may also be included because they are important differential diagnoses. This study will establish a large prospective cohort study database of Chinese IDD, which will record detailed electronic information on IDD patients, including demographic and socioeconomic data, medical history, clinical information, medication, and relevant examination results. The long-term observational study will be used to understand the natural history of disease, disability progression rates, imaging and biological indicators, long-term treatment approaches and prognosis of Chinese patients with IDD, to find predictive markers for IDD progression and prognosis, and to identify factors that influence the treatment and prognosis of patients with IDD.

Key facts

Study ID

NCT05154370

Run by

Beijing Tiantan Hospital

People needed

10000

Starts

2021-12-15

Expected to finish

2026-11-01

Last updated by the study team

2023-07-21

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. No requirement for age and sex
• 2. Need to meet the diagnosis of at least one IDD (clinically isolated syndrome (CIS)/multiple sclerosis (MS)/neuromyelitis optica spectrum disorder (NMOSD)/MOG antibody-associated disease (MOGAD)/acute disseminated encephalomyelitis (ADEM).
• 3. Signed informed consent form.

You may not qualify if…

• Those with severe mental disease unable to cooperate with the examination and/or follow-up.
• Any patient (or the patient's legal representative) who is unable or refuses to sign informed consent.

Where it is running

• Beijing Tiantan Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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