EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure

Recruiting now

Conditions studied: Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome

In brief

We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). We also attempt to identify what clinical, radiological, physiological and biological variables collected early in the course of AHRF correlate with subsequent mortality and/or persistent severe hypoxemia.

Key facts

Study ID

NCT05150483

Run by

Evangelismos Hospital

People needed

250

Starts

2021-12-10

Expected to finish

2026-04-30

Last updated by the study team

2025-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (aged >18 years) presenting in the emergency department
• De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)

You may not qualify if…

• Age <18 years
• Not admitted to the hospital
• Postoperative acute respiratory failure (within one week from surgery)
• Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)
• Hypercapnic respiratory failure
• Transferred from another hospital or facility
• Pregnant women
• Admitted to the hospital purely to facilitate comfort care
• Lack of informed consent

Where it is running

• Evangelismos Hospital — Athens, Attica, Greece (enrolling)

Full record on ClinicalTrials.gov

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