Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer
Recruiting now · Not applicable
Conditions studied: Radiotherapy; Complications
In brief
The aim of this randomized study is to investigate local tumor control,survival outcomes and complications on patients of liver metastasis in small cell lung cancer.
Key facts
- Study ID
- NCT05150145
- Run by
- Guizhou Medical University
- People needed
- 66
- Starts
- 2021-04-30
- Expected to finish
- 2026-03-01
- Last updated by the study team
- 2025-06-26
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed consent (radiation, medication) before treatment;
- Age 18 to 70 years old,regardless of gender;
- Initial SCLC confirmed by histopathological or cytological examination;
- Metastatic lesions in the distant area: included liver metastasis；
- Physical status score ECOG: 0 to 2；
- The expected survival time is more than 3 months;
- Bone marrow function:hemoglobin(HGB)>90g/L,platelet(PLT)>100×109/L,neutrophil cell(WBC)>1.5×109/L(*normal value);
- Liver function:alanine aminotransferase(ALT) and aspertate aminotransferase(AST)<1.5 times of the upper limit of normal(ULN);Total bilirubin <1.5ULN;
- Renal function:Serum creatinine was lower than 1.5ULN,and the endogenous creatinine clearance rate(Ccr) is higher than 55mL/min;
- Initial treatment (previously did not receive any thoracic radiotherapy or surgery).
You may not qualify if…
- patients with history of mental illness;
- patients combined with other malignancies;
- Active period of disease caused by bacteria, fungi or viruses; and these severe infection requiring intravenous antibiotics,antifungal or antiviral therapy;
- Patients with serious cardiovascular disease ,including uncontrolled hypertension, unstable angina,history of myocardial infarction within the past 12 months,and severe arrhythmias.
- Patients with poorly controlled diabetes who are judged to be unfit for chemotherapy by doctors.
- History of hepatitis and cirrhosisi ;
- pregnant, lactating patients;
- Patients with poor compliance；
- Researchers believe that it is not appropriate to participate in this test.
Where it is running
- The affiliated hospital of Guizhou medical university — Guiyang, Guizhou, China (enrolling)
Full record on ClinicalTrials.gov
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