Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Recruiting now · Not applicable

Conditions studied: Physical Inactivity, Phosphate Overload, Visceral Obesity

In brief

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Key facts

Study ID

NCT05147909

Run by

University of Texas Southwestern Medical Center

People needed

124

Starts

2022-09-14

Expected to finish

2028-03-30

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.

You may not qualify if…

• history of cardiopulmonary disease or chronic kidney disease,
• treatment with antihypertensive medications,
• estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness,
• (5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus < 2.4 or > 4.5 mg/dL.

Where it is running

• University of Texas Southwestern — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.